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The UPort 1200/1400/1600 Series macOS driver supports the following
UPort devices:
  UPort 1250/1250I
  UPort 1410/1450/1450I
  UPort 1610-8/1650-8
  UPort 1610-16/1650-16
  UPort 1250-G2, UPort 1250I-G2,
  UPort 1410-G2, UPort 1450-G2, UPort 1450I-G2,
  UPort 1610-8-G2, UPort 1650-8-G2, 
  UPort 1650-8-G2-HUB, UPort 1650I-8-G2

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Prerequisite
  - Hardware platform: Intel x86/x64 machine
  - USB Standard: USB 1.1/2.0 compliant
  - OS version: macOS 10.12 to 13
  - Turn off System Integrity Protection (SIP). Please refer
    to the "Troubleshooting" section to learn how to enter
    Recovery Mode.

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Troubleshooting
   Turn off System Integrity Protection (SIP)
   1. Reboot the Mac and hold command ⌘+R, entering Recovery
      Mode.
   2. Launch the terminal
   3. Type 'csrutil disable'
   4. Reboot the Mac again and return to Normal Mode
   5. Relaunch the UPort driver installer and complete
      the installation.

   After the UPort driver has been installed successfully, you
   may want to reenable SIP with the following steps:
   1. Reboot the Mac and hold command ⌘+R, entering Recovery
      Mode.
   2. Launch the terminal
   3. Type 'csrutil enable'
   4. Reboot the Mac again and return to Normal Mode

   You might not be able to install the driver on macOS 10.15 successfully,
   starting with macOS 10.15 Catalina, Apple has introduced a new
   read-only protection that does not allow users to install directly 
   in the kernel folder.
   To solve this issue, please type the following command in
   the terminal before installation:

     $ sudo mount -uw /